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Complementary pharmacokinetic measures to further define the profile of once-daily OROS hydromorphone ER during single-dose and steady-state dosing

Conventional measures such as maximum plasma concentration (C(max)) and area under the concentration versus time curve (AUC) may be insufficient to fully describe the pharmacokinetic (PK) profile of extended-release (ER) formulations. A complementary measure, the half-value duration (HVD), correspon...

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Bibliografski detalji
Glavni autori: Devarakonda, Krishna, Vandenbossche, Joris, Richarz, Ute
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863398/
https://ncbi.nlm.nih.gov/pubmed/24349945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-2-625
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