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Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR.

2-Aminopurine (AP), a potent mutagenic base analogue, most frequently pairs with thymine. In the AP X T base pair, both bases adopt normal tautomeric forms. The mechanism for the mutagenic activity arises from its observed pairing with cytosine, which has been ascribed to an enhanced tendency to ado...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Sowers, L C, Fazakerley, G V, Eritja, R, Kaplan, B E, Goodman, M F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 1986
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Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386301/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3461441/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.15.5434
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