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Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR.

2-Aminopurine (AP), a potent mutagenic base analogue, most frequently pairs with thymine. In the AP X T base pair, both bases adopt normal tautomeric forms. The mechanism for the mutagenic activity arises from its observed pairing with cytosine, which has been ascribed to an enhanced tendency to ado...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sowers, L C, Fazakerley, G V, Eritja, R, Kaplan, B E, Goodman, M F
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386301/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3461441/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.15.5434
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