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PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity

Two major mechanisms of intracellular protein degradation, autophagy and the ubiquitin-proteasome pathway, operate in mammalian cells. PTEN, which is frequently mutated in glioblastomas, is a tumor suppressor gene that encodes a dual specificity phosphatase that antagonizes the phosphatidylinositol...

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Main Authors: Errafiy, Rajaa, Aguado, Carmen, Ghislat, Ghita, Esteve, Juan M., Gil, Anabel, Loutfi, Mohammed, Knecht, Erwin
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862694/
https://ncbi.nlm.nih.gov/pubmed/24349488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083318
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