PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity

Two major mechanisms of intracellular protein degradation, autophagy and the ubiquitin-proteasome pathway, operate in mammalian cells. PTEN, which is frequently mutated in glioblastomas, is a tumor suppressor gene that encodes a dual specificity phosphatase that antagonizes the phosphatidylinositol...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Errafiy, Rajaa, Aguado, Carmen, Ghislat, Ghita, Esteve, Juan M., Gil, Anabel, Loutfi, Mohammed, Knecht, Erwin
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862694/
https://ncbi.nlm.nih.gov/pubmed/24349488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083318
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