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A common signaling pathway is activated in erythroid cells expressing high levels of fetal hemoglobin: a potential role for cAMP-elevating agents in β-globin disorders

BACKGROUND: Although erythroid cells prepared from fetal liver, cord blood, or blood from β-thalassemia patients are known to express fetal hemoglobin at high levels, the underlying mechanisms remain elusive. We previously showed that cyclic nucleotides such as cAMP and cGMP induce fetal hemoglobin...

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מידע ביבליוגרפי
Main Authors: Ikuta, Tohru, Kuroyanagi, Yuichi, Odo, Nadine, Liu, Siyang
פורמט: Artigo
שפה:Inglês
יצא לאור: Dove Medical Press 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862583/
https://ncbi.nlm.nih.gov/pubmed/24353450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JBM.S54671
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