Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies

OZ78 and MT04 are promising drug candidates against fascioliasis (fasciolosis). We determined basic pharmacokinetic (PK) parameters of OZ78 and MT04 in uninfected rats. Rats were treated with single oral doses of 50 mg/kg OZ78 or MT04. Blood samples were withdrawn at selected time points post treatm...

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Hlavní autoři: Kirchhofer, Carla, Vargas, Mireille, Huwyler, Jörg, Keiser, Jennifer
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2012
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862416/
https://ncbi.nlm.nih.gov/pubmed/24533273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.03.003
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