BLT-humanized C57BL/6 Rag2(−/−)γ(c)(−/−)CD47(−/−) mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

The use of C57BL/6 Rag2(−/−)γ(c)(−/−) mice as recipients for xenotransplantation with human immune systems (humanization) has been problematic because C57BL/6 SIRPα does not recognize human CD47, and such recognition is required to suppress macrophage-mediated phagocytosis of transplanted human hema...

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Detalhes bibliográficos
Main Authors: Lavender, Kerry J., Pang, Wendy W., Messer, Ronald J., Duley, Amanda K., Race, Brent, Phillips, Katie, Scott, Dana, Peterson, Karin E., Chan, Charles K., Dittmer, Ulf, Dudek, Timothy, Allen, Todd M., Weissman, Irving L., Hasenkrug, Kim J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862274/
https://ncbi.nlm.nih.gov/pubmed/24021673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-506949
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