Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation

► Nintedanib is an anti-angiogenic agent that has demonstrated activity in relapsed ovarian cancer. ► Our patient had prolonged response to nintedanib, allowing her to have potentially curative surgery 6 years after her diagnosis. ► The relationship between angiogenesis and BRCA mutation is worth ex...

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Autori principali: Wong, Han Hsi, Parkinson, Christine, Ledermann, Jonathan A., Brenton, James D., Merger, Michael, Shaw, Ashley, Patterson, Aileen, Shafi, Mahmood, Earl, Helena M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2012
Soggetti:
Case Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862224/
https://ncbi.nlm.nih.gov/pubmed/24371652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gynor.2012.10.003
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