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HIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern

Drug resistance of HIV-1 protease alters the balance in the molecular recognition events in favor of substrate processing versus inhibitor binding. To develop robust inhibitors targeting ensembles of drug-resistant variants, the code of this balance needs to be cracked. For this purpose, the princip...

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Bibliografiska uppgifter
Huvudupphovsmän: Özen, Ayşegül, Haliloğlu, Türkan, Schiffer, Celia A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862175/
https://ncbi.nlm.nih.gov/pubmed/24348205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct200668a
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