Cerebrospinal-fluid-derived Immunoglobulin G of Different Multiple Sclerosis Patients Shares Mutated Sequences in Complementarity Determining Regions

B lymphocytes play a pivotal role in multiple sclerosis pathology, possibly via both antibody-dependent and -independent pathways. Intrathecal immunoglobulin G in multiple sclerosis is produced by clonally expanded B-cell populations. Recent studies indicate that the complementarity determining regi...

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Autors principals: Singh, Vaibhav, Stoop, Marcel P., Stingl, Christoph, Luitwieler, Ronald L., Dekker, Lennard J., van Duijn, Martijn M., Kreft, Karim L., Luider, Theo M., Hintzen, Rogier Q.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861734/
https://ncbi.nlm.nih.gov/pubmed/23970564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.030346
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