Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells

Vimentin, a type III intermediate filament (IF) protein, is phosphorylated predominantly in mitosis. The expression of a phosphorylation-compromised vimentin mutant in T24 cultured cells leads to cytokinetic failure, resulting in binucleation (multinucleation). The physiological significance of inte...

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Bibliographic Details
Main Authors: Matsuyama, Makoto, Tanaka, Hiroki, Inoko, Akihito, Goto, Hidemasa, Yonemura, Shigenobu, Kobori, Kyoko, Hayashi, Yuko, Kondo, Eisaku, Itohara, Shigeyoshi, Izawa, Ichiro, Inagaki, Masaki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861614/
https://ncbi.nlm.nih.gov/pubmed/24142690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514737
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