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Deletion of C9ORF72 Results in Motor Neuron Degeneration and Stress Sensitivity in C. elegans
An expansion of the hexanucleotide GGGGCC repeat in the first intron of C9ORF72 gene was recently linked to amyotrophic lateral sclerosis. It is not known if the mutation results in a gain of function, a loss of function or if, perhaps both mechanisms are linked to pathogenesis. We generated a genet...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3861484/ https://ncbi.nlm.nih.gov/pubmed/24349511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083450 |
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