Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

OBJECTIVES: The introduction of two new non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the past 5 years and the identification of novel NNRTI-associated mutations have made it necessary to reassess the extent of phenotypic NNRTI cross-resistance. METHODS: We analysed a dataset containin...

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Hauptverfasser: Melikian, George L., Rhee, Soo-Yon, Varghese, Vici, Porter, Danielle, White, Kirsten, Taylor, Jonathan, Towner, William, Troia, Paolo, Burack, Jeffrey, DeJesus, Edwin, Robbins, Gregory K., Razzeca, Kristin, Kagan, Ron, Liu, Tommy F., Fessel, W. Jeffrey, Israelski, Dennis, Shafer, Robert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861329/
https://ncbi.nlm.nih.gov/pubmed/23934770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt316
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