CB1 and CB2 Receptors are Novel Molecular Targets for Tamoxifen and 4OH-Tamoxifen

Tamoxifen (Tam) is classified as a selective estrogen receptor modulator (SERM) and is used for treatment of patients with ER-positive breast cancer. However, it has been shown that Tam and its cytochrome P450-generated metabolite 4-hydroxy-Tam (4OH-Tam) also exhibit cytotoxic effects in ER-negative...

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Bibliographic Details
Main Authors: Prather, Paul L., FrancisDevaraj, FeAna, Dates, Centdrika R., Greer, Aleksandra K., Bratton, Stacie M., Ford, Benjamin M., Franks, Lirit N., Radominska-Pandya, Anna
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860589/
https://ncbi.nlm.nih.gov/pubmed/24148245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.10.057
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