Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells

BACKGROUND: Persin is a plant toxin that displays synergistic cytotoxicity with tamoxifen in human breast cancer cell lines. Here, we examined the ability of persin to circumvent tamoxifen resistance and delineated the intracellular signalling pathways involved. METHODS: The induction of apoptosis i...

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Detalhes bibliográficos
Main Authors: McCloy, R A, Shelley, E J, Roberts, C G, Boslem, E, Biden, T J, Nicholson, R I, Gee, J M, Sutherland, R L, Musgrove, E A, Burgess, A, Butt, A J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859954/
https://ncbi.nlm.nih.gov/pubmed/24178758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.693
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