HDAC inhibitor confers radiosensitivity to prostate stem-like cells

BACKGROUND: Radiotherapy can be an effective treatment for prostate cancer, but radiorecurrent tumours do develop. Considering prostate cancer heterogeneity, we hypothesised that primitive stem-like cells may constitute the radiation-resistant fraction. METHODS: Primary cultures were derived from pa...

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Autori principali: Frame, F M, Pellacani, D, Collins, A T, Simms, M S, Mann, V M, Jones, GDD, Meuth, M, Bristow, R G, Maitland, N J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859953/
https://ncbi.nlm.nih.gov/pubmed/24220693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.691
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