Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer

BACKGROUND: We evaluated the clinical prognostic value of methylation of two non-coding repeat sequences, long interspersed element 1 (LINE-1) and Alu, in rectal tumour tissues. In addition to DNA methylation, expression of histone modifications H3K27me3 and H3K9Ac was studied in this patient cohort...

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Hlavní autoři: Benard, A, van de Velde, C J H, Lessard, L, Putter, H, Takeshima, L, Kuppen, P J K, Hoon, D S B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859941/
https://ncbi.nlm.nih.gov/pubmed/24220694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.654
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