KRAS-mutated plasma DNA as predictor of outcome from irinotecan monotherapy in metastatic colorectal cancer

BACKGROUND: We investigated the clinical implications of KRAS and BRAF mutations detected in both archival tumor tissue and plasma cell-free DNA in metastatic colorectal cancer patients treated with irinotecan monotherapy. METHODS: Two hundred and eleven patients receiving second-line irinotecan (35...

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Autors principals: Spindler, K G, Appelt, A L, Pallisgaard, N, Andersen, R F, Jakobsen, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Molecular Diagnostics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859936/
https://ncbi.nlm.nih.gov/pubmed/24263065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.633
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