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Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein
Glucokinase (GCK) is responsible for maintaining glucose homeostasis in the human body. Dysfunction or misregulation of GCK causes hyperinsulinemia, hypertriglyceridemia and type 2 diabetes. In the liver GCK is regulated by interaction with the glucokinase regulatory protein (GKRP), a 68-kDa polypep...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859847/ https://ncbi.nlm.nih.gov/pubmed/23957911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400838t |
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