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Effects of Direct Renin Inhibition on Myocardial Fibrosis and Cardiac Fibroblast Function
Myocardial fibrosis, a major pathophysiologic substrate of heart failure with preserved ejection fraction (HFPEF), is modulated by multiple pathways including the renin-angiotensin system. Direct renin inhibition is a promising anti-fibrotic therapy since it attenuates the pro-fibrotic effects of re...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859492/ https://ncbi.nlm.nih.gov/pubmed/24349097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081612 |
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