Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

Chronic pain is a major clinical problem, yet the mechanisms underlying the transition from acute to chronic pain remain poorly understood. In mice, reduced expression of GPCR kinase 2 (GRK2) in nociceptors promotes cAMP signaling to the guanine nucleotide exchange factor EPAC1 and prolongs the PGE(...

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Bibliographic Details
Main Authors: Wang, Huijing, Heijnen, Cobi J., van Velthoven, Cindy T.J., Willemen, Hanneke L.D.M., Ishikawa, Yoshihiro, Zhang, Xinna, Sood, Anil K., Vroon, Anne, Eijkelkamp, Niels, Kavelaars, Annemieke
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859388/
https://ncbi.nlm.nih.gov/pubmed/24231349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66241
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