APC mutations in colorectal tumors with mismatch repair deficiency.

We have investigated the influence of genetic instability [replication error (RER) phenotype] on APC (adenomatous polyposis coli), a gene thought to initiate colorectal tumorigenesis. The prevalence of APC mutations was similar in RER and non-RER tumors, indicating that both tumor types share this s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Huang, J, Papadopoulos, N, McKinley, A J, Farrington, S M, Curtis, L J, Wyllie, A H, Zheng, S, Willson, J K, Markowitz, S D, Morin, P, Kinzler, K W, Vogelstein, B, Dunlop, M G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8799152/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.17.9049
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