APC mutations in colorectal tumors with mismatch repair deficiency.

We have investigated the influence of genetic instability [replication error (RER) phenotype] on APC (adenomatous polyposis coli), a gene thought to initiate colorectal tumorigenesis. The prevalence of APC mutations was similar in RER and non-RER tumors, indicating that both tumor types share this s...

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Dettagli Bibliografici
Autori principali: Huang, J, Papadopoulos, N, McKinley, A J, Farrington, S M, Curtis, L J, Wyllie, A H, Zheng, S, Willson, J K, Markowitz, S D, Morin, P, Kinzler, K W, Vogelstein, B, Dunlop, M G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC38593/
https://ncbi.nlm.nih.gov/pubmed/8799152
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