Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). However, the endogenous ligand responsible for TLR2 activation has not yet been detected. The objective of this study was to identify HMGB1 as an activator of TLR2 signa...

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Detalhes bibliográficos
Main Authors: Mersmann, Jan, Iskandar, Franziska, Latsch, Kathrina, Habeck, Katharina, Sprunck, Vera, Zimmermann, René, Schumann, Ralf R., Zacharowski, Kai, Koch, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859028/
https://ncbi.nlm.nih.gov/pubmed/24371373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/174168
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