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Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751

OBJECTIVE: ABT-751, a novel orally available antitubulin agent, is mainly eliminated as inactive glucuronide (ABT-751G) and sulfate (ABT-751S) conjugates. We performed a pharmacogenetic investigation of ABT-751 pharmacokinetics using in-vitro data to guide the selection of genes for genotyping in a...

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Detalhes bibliográficos
Main Authors: Innocenti, Federico, Ramírez, Jacqueline, Obel, Jennifer, Xiong, Julia, Mirkov, Snezana, Chiu, Yi-Lin, Katz, David A., Carr, Robert A., Zhang, Wei, Das, Soma, Adjei, Araba, Moyer, Ann M., Chen, Pei Xian, Krivoshik, Andrew, Medina, Diane, Gordon, Gary B., Ratain, Mark J., Sahelijo, Leonardo, Weinshilboum, Richard M., Fleming, Gini F., Bhathena, Anahita
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858967/
https://ncbi.nlm.nih.gov/pubmed/23670235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283623e81
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