Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751

OBJECTIVE: ABT-751, a novel orally available antitubulin agent, is mainly eliminated as inactive glucuronide (ABT-751G) and sulfate (ABT-751S) conjugates. We performed a pharmacogenetic investigation of ABT-751 pharmacokinetics using in-vitro data to guide the selection of genes for genotyping in a...

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Bibliografische gegevens
Hoofdauteurs: Innocenti, Federico, Ramírez, Jacqueline, Obel, Jennifer, Xiong, Julia, Mirkov, Snezana, Chiu, Yi-Lin, Katz, David A., Carr, Robert A., Zhang, Wei, Das, Soma, Adjei, Araba, Moyer, Ann M., Chen, Pei Xian, Krivoshik, Andrew, Medina, Diane, Gordon, Gary B., Ratain, Mark J., Sahelijo, Leonardo, Weinshilboum, Richard M., Fleming, Gini F., Bhathena, Anahita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858967/
https://ncbi.nlm.nih.gov/pubmed/23670235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283623e81
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