Acute Hyperglycemia Abolishes Ischemic Preconditioning by Inhibiting Akt Phosphorylation: Normalizing Blood Glucose before Ischemia Restores Ischemic Preconditioning

This study examined the hypothesis that acute hyperglycemia (HG) blocks ischemic preconditioning (IPC) by inhibiting Akt phosphorylation. Brief HG of approximately 400 mg/dL was induced in C57BL/6 mice via intraperitoneal injection of 20% dextrose (2 g/kg). All mice underwent 40 min LAD occlusion an...

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Detalhes bibliográficos
Main Authors: Yang, Zequan, Tian, Yikui, Liu, Yuan, Hennessy, Sara, Kron, Irving L., French, Brent A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858874/
https://ncbi.nlm.nih.gov/pubmed/24371503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/329183
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