Differences in the Cellular Uptake and Intracellular Itineraries of Amyloid Beta Proteins 40 and 42: Ramifications for the Alzheimer’s Drug Discovery

[Image: see text] Mounting evidence suggests that the pathological hallmarks of Alzheimer’s disease (AD), neurofibrillary tangles and parenchymal amyloid plaques, are downstream reflections of neurodegeneration caused by the intraneuronal accumulation of amyloid-β proteins (Aβ), particularly Aβ42 an...

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Bibliographic Details
Main Authors: Omtri, Rajesh S., Davidson, Michael W., Arumugam, Balasubramaniam, Poduslo, Joseph F., Kandimalla, Karunya K.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858471/
https://ncbi.nlm.nih.gov/pubmed/22574751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200530q
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