Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal Inflammation

BACKGROUND: Lipotoxicity is a key feature of the pathogenesis of diabetic kidney disease, and is attributed to excessive lipid accumulation (hyperlipidemia). Increasing evidence suggests that fibroblast growth factor (FGF)21 has a crucial role in lipid metabolism under diabetic conditions. OBJECTIVE...

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Detalhes bibliográficos
Main Authors: Zhang, Chi, Shao, Minglong, Yang, Hong, Chen, Liangmiao, Yu, Lechu, Cong, Weitao, Tian, Haishan, Zhang, Fangfang, Cheng, Peng, Jin, Litai, Tan, Yi, Li, Xiaokun, Cai, Lu, Lu, Xuemian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857822/
https://ncbi.nlm.nih.gov/pubmed/24349242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082275
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