Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the suppressing renal connective tissue growth factor e...

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Bibliografske podrobnosti
izdano v:Diabetes Metab J
Main Authors: Lin, Sundong, Yu, Lechu, Ni, Yongqing, He, Lulu, Weng, Xiaolu, Lu, Xuemian, Zhang, Chi
Format: Artigo
Jezik:Inglês
Izdano: Korean Diabetes Association 2020
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043973/
https://ncbi.nlm.nih.gov/pubmed/31701691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4093/dmj.2018.0235
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