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Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice

Oleanolic acid (OA) is a triterpenoids that exists widely in plants. OA is effective in protecting against hepatotoxicants. Whereas a low dose of OA is hepatoprotective, higher doses and longer-term use of OA produce liver injury. This study characterized OA-induced liver injury in mice. Adult C57BL...

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Detalhes bibliográficos
Main Authors: Liu, Jie, Lu, Yuan-Fu, Zhang, Youcai, Wu, Kai Connie, Fan, Fang, Klaassen, Curtis D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857557/
https://ncbi.nlm.nih.gov/pubmed/23948738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.08.003
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