Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin

Brostallicin is a DNA minor groove binder that shows enhanced antitumor activity in cells with high glutathione S-transferase (GST)/glutathione content. Prostate cancer cells present, almost invariably, methylation of the GSTP1 gene promoter and, as a consequence, low levels of GST-pi expression and...

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Библиографические подробности
Главные авторы: Sabatino, Maria Antonietta, Geroni, Cristina, Ganzinelli, Monica, Ceruti, Roberta, Broggini, Massimo
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2013
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857345/
https://ncbi.nlm.nih.gov/pubmed/23771052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.24916
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