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CoCEST: Cobalt(II) Amide-Appended ParaCEST MRI Contrast Agents

The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

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Bibliografiske detaljer
Main Authors: Dorazio, Sarina J., Olatunde, Abiola O., Spernyak, Joseph A., Morrow, Janet R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857136/
https://ncbi.nlm.nih.gov/pubmed/24045271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc45000g
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