Deficiency of GRP94 in the Hematopoietic System Alters Proliferation Regulators in Hematopoietic Stem Cells

We have previously reported that acute inducible knockout of the endoplasmic reticulum chaperone GRP94 led to an expansion of the hematopoietic stem and progenitor cell pool. Here, we investigated the effectors and mechanisms for this phenomenon. We observed an increase in AKT activation in freshly...

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Bibliographic Details
Main Authors: Luo, Biquan, Tseng, Chun-Chih, Adams, Gregor B., Lee, Amy S.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2013
Subjects:
Original Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856911/
https://ncbi.nlm.nih.gov/pubmed/23859598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0181
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