Succinate Dehydrogenase Kidney Cancer (SDH-RCC): An Aggressive Example of the Warburg Effect in Cancer

PURPOSE: Recently, a new renal cell cancer (RCC) syndrome has been linked to germline mutation of multiple subunits (SDHB/C/D) of the Krebs cycle enzyme, succinate dehydrogenase. We report our experience with diagnosis, evaluation and treatment of this novel form of hereditary kidney cancer. MATERIA...

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Main Authors: Ricketts, Christopher J., Shuch, Brian, Vocke, Cathy D., Metwalli, Adam R., Bratslavsky, Gennady, Middelton, Lindsay, Yang, Youfeng, Wei, Ming-Hui, Pautler, Stephen E., Peterson, James, Stolle, Catherine A., Zbar, Berton, Merino, Maria J., Schmidt, Laura S., Pinto, Peter A., Srinivasan, Ramaprasad, Pacak, Karel, Linehan, W. Marston
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856891/
https://ncbi.nlm.nih.gov/pubmed/23083876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2012.08.030
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