Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets

In prostate cancer, multiple metastases from the same patient share similar copy number, mutational status, erythroblast transformation specific (ETS) rearrangements, and methylation patterns supporting their clonal origins. Whether actionable targets such as tyrosine kinases are also similarly expr...

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Bibliografiske detaljer
Main Authors: Drake, Justin M., Graham, Nicholas A., Lee, John K., Stoyanova, Tanya, Faltermeier, Claire M., Sud, Sudha, Titz, Björn, Huang, Jiaoti, Pienta, Kenneth J., Graeber, Thomas G., Witte, Owen N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856845/
https://ncbi.nlm.nih.gov/pubmed/24248375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319948110
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