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Genetic variants in Selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics

CONTEXT: Insulin resistance is not fully explained on a molecular level, though several genes and proteins have been tied to this defect. Knockdowns of the SEPP1 gene, which encodes the Selenoprotein P (SeP) protein, have been shown to increase insulin sensitivity in mice. SeP is a liver-derived pla...

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Bibliographic Details
Main Authors: Hellwege, Jacklyn N., Palmer, Nicholette D., Ziegler, Julie T., Langefeld, Carl D., Lorenzo, Carlos, Norris, Jill M., Takamura, Toshinari, Bowden, Donald W.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856675/
https://ncbi.nlm.nih.gov/pubmed/24161883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2013.10.035
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