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Impaired Oral Tolerance Induction in Diabetes Prone but not in Diabetes Resistant Mice Revealed by Cholera Toxin Subunit B-Peptide Fusion Proteins

The B subunit of cholera toxin (CTB) has been used as adjuvant to improve oral vaccine delivery in type 1 diabetes. The effect of CTB/peptide formulations on antigen-specific CD4 T cells has remained largely unexplored. We investigated by tetramer analysis how oral delivery of CTB fused to 2 CD4 T c...

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Detalhes bibliográficos
Main Authors: Presa, Maximiliano, Ortiz, Angela Zarama, Garabatos, Nahir, Izquierdo, Cristina, Rivas, Elisa I., Teyton, Luc, Mora, Conchi, Serreze, David, Stratmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856580/
https://ncbi.nlm.nih.gov/pubmed/23925934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343633
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