Genetic Variation near IRF8 is Associated with Serologic and Cytokine Profiles in Systemic Lupus Erythematosus and Multiple Sclerosis

Alleles of IRF8 are associated with susceptibility to both systemic lupus erythematosus (SLE) and multiple sclerosis (MS). While high type I interferon (IFN) is thought to be causal in SLE, type I IFN is used as a therapy in MS. We investigated whether IRF8 alleles were associated with type I IFN le...

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Detalhes bibliográficos
Main Authors: Chrabot, Beverly S., Kariuki, Silvia N., Zervou, Maria I., Feng, Xuan, Arrington, Jasmine, Jolly, Meenakshi, Boumpas, Dimitrios T., Reder, Anthony T., Goulielmos, George N., Niewold, Timothy B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856198/
https://ncbi.nlm.nih.gov/pubmed/23965942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2013.42
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