DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats

The tumor suppressor p53 has an important role in inducing cell-intrinsic responses to DNA damage, including cellular senescence or apoptosis, which act to thwart tumor development. It has been shown, however, that senescent or dying cells are capable of eliciting inflammatory responses, which can h...

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Bibliographic Details
Main Authors:	Yan, H-X, Wu, H-P, Zhang, H-L, Ashton, C, Tong, C, Wu, J, Qian, Q-J, Wang, H-Y, Ying, Q-L
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3855850/ https://ncbi.nlm.nih.gov/pubmed/23069657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.451
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DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats

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