5-Aminolevulinic Acid Protects against Cisplatin-Induced Nephrotoxicity without Compromising the Anticancer Efficiency of Cisplatin in Rats In Vitro and In Vivo

BACKGROUND/AIMS: Nephrotoxicity is a frequent and major limitation in cisplatin (CDDP)-based chemotherapy. 5-Aminolevulinic acid (ALA) is widely distributed in animal cells, and it is a precursor of tetrapyrole compounds such as heme that is fundamentally important in aerobic energy metabolism. The...

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Autori principali: Terada, Yoshio, Inoue, Keiji, Matsumoto, Tatsuki, Ishihara, Masayuki, Hamada, Kazu, Shimamura, Yoshiko, Ogata, Koji, Inoue, Kosuke, Taniguchi, Yoshinori, Horino, Taro, Karashima, Takashi, Tamura, Kenji, Fukuhara, Hideo, Fujimoto, Shimpei, Tsuda, Masayuki, Shuin, Taro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855642/
https://ncbi.nlm.nih.gov/pubmed/24324635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080850
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