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A simple one-pot 2-step N-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles

A straightforward procedure for the preparation of N-quinoxaline-indoles is presented. A base-catalyzed one-pot addition of indoles to a preformed α-iminoketone proceeds on the N-1 indole and the subsequent adduct undergoes an acid-mediated deprotection of an internal amino nucleophile, intramolecul...

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Détails bibliographiques
Auteurs principaux: Martinez-Ariza, Guillermo, Ayaz, Muhammad, Hulme, Christopher
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855464/
https://ncbi.nlm.nih.gov/pubmed/24327792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.09.113
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