Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells

Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular response to low oxygen. Although HIF-1 is usually considered as the principal mediator of hypoxic adaptation, several tissues and different cell types express both HIF-1 and HIF-2 isoforms under hypoxia or when...

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Autores principales: Befani, Christina, Mylonis, Ilias, Gkotinakou, Ioanna-Maria, Georgoulias, Panagiotis, Hu, Cheng-Jun, Simos, George, Liakos, Panagiotis
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855297/
https://ncbi.nlm.nih.gov/pubmed/23958427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2013.07.025
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