Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila

Obesity is defined by excessive lipid accumulation. However, the active mechanistic roles that lipids play in its progression are not understood. Accumulation of ceramide, the metabolic hub of sphingolipid metabolism, has been associated with metabolic syndrome and obesity in humans and model system...

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Detalhes bibliográficos
Main Authors: Walls, Stanley M., Attle, Steve J., Brulte, Gregory B., Walls, Marlena L., Finley, Kim D., Chatfield, Dale A., Herr, Deron R., Harris, Greg L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854795/
https://ncbi.nlm.nih.gov/pubmed/24339790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003970
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