In Vitro and In Vivo Antagonism of a G Protein-Coupled Receptor (S1P(3)) with a Novel Blocking Monoclonal Antibody

BACKGROUND: S1P(3) is a lipid-activated G protein-couple receptor (GPCR) that has been implicated in the pathological processes of a number of diseases, including sepsis and cancer. Currently, there are no available high-affinity, subtype-selective drug compounds that can block activation of S1P(3)....

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Bibliographic Details
Main Authors: Harris, Greg L., Creason, Michael B., Brulte, Greg B., Herr, Deron R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320623/
https://ncbi.nlm.nih.gov/pubmed/22496900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035129
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