Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status

INTRODUCTION: The reprogramming of a patient’s somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially oncogenic transgenic elements following reprogramming, however, represents a safe...

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Autori principali: Awe, Jason P, Lee, Patrick C, Ramathal, Cyril, Vega-Crespo, Agustin, Durruthy-Durruthy, Jens, Cooper, Aaron, Karumbayaram, Saravanan, Lowry, William E, Clark, Amander T, Zack, Jerome A, Sebastiano, Vittorio, Kohn, Donald B, Pyle, April D, Martin, Martin G, Lipshutz, Gerald S, Phelps, Patricia E, Pera, Renee A Reijo, Byrne, James A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854769/
https://ncbi.nlm.nih.gov/pubmed/23890092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt246
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