A Multiplexed Fluorescent Calcium and NFAT Reporter Gene Assay to Identify GPCR Agonists

Intracellular calcium response and resulting calcium signaling to an agonist-GPCR interaction are important for the measurement of compound activity in the GPCR drug development. The increase in cytosol calcium concentration can be measured by the fluorescent calcium indicator dye such as Fluo-4 in...

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Detalhes bibliográficos
Main Authors: Sheth, Heeral, Gorey, Colleen, Roush, Nicole, Smallman, Shelly, Collantes, Elizabeth, Santoro, Maxine, Olson, Barbara, Fitzgerald, Laura, Lee, Paul H, Shen, Xiqiang John
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Open 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854663/
https://ncbi.nlm.nih.gov/pubmed/24396729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/2213988501307010001
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