Inherited common variants in mitochondrial DNA and invasive serous epithelial ovarian cancer risk

BACKGROUND: Mitochondria are the site of oxidative phosphorylation, a process which generates reactive oxygen species (ROS). Elevated ROS levels can lead to oxidative stress, a cellular state implicated in carcinogenesis. It is hypothesized that alternations in mitochondrial (MT) DNA, including heri...

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Main Authors: Earp, Madalene A, Brooks-Wilson, Angela, Cook, Linda, Le, Nhu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854008/
https://ncbi.nlm.nih.gov/pubmed/24148579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-6-425
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