Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease

IGF-1 has been associated with the pathogenesis of diabetic retinopathy, although its role is not fully understood. Here we show that normoglycemic/normoinsulinemic transgenic mice overexpressing IGF-1 in the retina developed most alterations seen in human diabetic eye disease. A paracrine effect of...

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Hauptverfasser: Ruberte, Jesús, Ayuso, Eduard, Navarro, Marc, Carretero, Ana, Nacher, Víctor, Haurigot, Virginia, George, Mónica, Llombart, Cristina, Casellas, Alba, Costa, Cristina, Bosch, Assumpció, Bosch, Fatima
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC385397/
https://ncbi.nlm.nih.gov/pubmed/15085194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419478
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