At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death

Back ground: Overt and subtle iron overload cause diabetes by lowering insulin production and promoting insulin resistance. Via divalent metal transporters pancreatic beta cells take up non-transferrin-bound iron which by catalyzing Fenton reaction can cause oxidative stress. Due to their strict dep...

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Bibliografske podrobnosti
Main Authors: Masuda, Yuichi, Ichii, Hirohito, Vaziri, Nosratola D
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853425/
https://ncbi.nlm.nih.gov/pubmed/24349622
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