At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death

Back ground: Overt and subtle iron overload cause diabetes by lowering insulin production and promoting insulin resistance. Via divalent metal transporters pancreatic beta cells take up non-transferrin-bound iron which by catalyzing Fenton reaction can cause oxidative stress. Due to their strict dep...

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Библиографические подробности
Главные авторы: Masuda, Yuichi, Ichii, Hirohito, Vaziri, Nosratola D
Формат: Artigo
Язык:Inglês
Опубликовано: e-Century Publishing Corporation 2013
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853425/
https://ncbi.nlm.nih.gov/pubmed/24349622
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